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Cells to Society: $3.4 Million in Grants / New FAANs / Research News
This study explores survivors’ perspectives on secondary prevention of campus sexual assault and effective strategies for intervention.     Read more   Mental Health ...
Source: Johns Hopkins University and Health Systems Archive - November 9, 2018 Category: Nursing Source Type: news

Predictors of 7- and 30-day mortality in pediatric intensive care unit patients with cancer and hematologic malignancy infected with Gram-negative bacteria.
CONCLUSIONS: shock was a predictor of 7- and 30-day mortality, and colonization by multidrug resistant-Gram-negative bacteria was an important risk factor for 30-day mortality. PMID: 25051279 [PubMed - as supplied by publisher]
Source: Braz J Infect Dis - July 19, 2014 Category: Infectious Diseases Authors: de Oliveira Costa P, Atta EH, da Silva AR Tags: Braz J Infect Dis Source Type: research

Critical illness in patients with metastatic cancer: a population-based cohort study of epidemiology and outcomes
The appropriateness of intensive care unit (ICU) admission of patients with metastatic cancer remains debated. We aimed to examine the short-term outcomes and their temporal pattern in critically ill patients with metastatic disease. We used state-wide data to identify hospitalizations aged ≥18 years with metastatic cancer admitted to ICU in Texas during 2010–2014. Multivariable logistic regression modeling was used to examine the factors associated with short-term mortality and its temporal trends among all ICU admissions and those undergoing mechanical ventilation. Among 136,644 ICU admissions with metastatic ca...
Source: Journal of Investigative Medicine - February 25, 2022 Category: Research Authors: Oud, L. Tags: Original research Source Type: research

Predictors of 7- and 30-day mortality in pediatric intensive care unit patients with cancer and hematologic malignancy infected with Gram-negative bacteria
Conclusions Shock was a predictor of 7- and 30-day mortality, and colonization by multidrug resistant-Gram-negative bacteria was an important risk factor for 30-day mortality.
Source: The Brazilian Journal of Infectious Diseases - November 22, 2014 Category: Infectious Diseases Source Type: research

The role of radiation therapy in palliative care of children with advanced cancer: Clinical outcomes and patterns of care
ConclusionsPalliative RT is effective in children with advanced cancer, although less so in the last 30 dol. With careful care coordination and multidisciplinary collaboration, RT can be successfully integrated into supportive and end‐of‐life care for children with advanced cancer.
Source: Pediatric Blood and Cancer - December 20, 2016 Category: Cancer & Oncology Authors: Sumeeta Varma, Debra L. Friedman, Mark J. Stavas Tags: Research Article Source Type: research

Malignant Mesothelioma: Has Anything Changed?
Semin Respir Crit Care Med 2019; 40: 347-360 DOI: 10.1055/s-0039-1693406Malignant pleural mesothelioma is a rare cancer associated with asbestos exposure and portends a dismal prognosis. Its worldwide incidence has been increasing, and treatment options are currently suboptimal and noncurative. However, since the turn of the century, several encouraging steps have been made toward improving outcomes for mesothelioma patients. An increased understanding of disease pathophysiology has led to more accurate diagnosis and staging, and the establishment of the standard of care first-line pemetrexed/platin doublet chemotherapy re...
Source: Seminars in Respiratory and Critical Care Medicine - September 15, 2019 Category: Respiratory Medicine Authors: Kim, Roger Y. Sterman, Daniel H. Haas, Andrew R. Tags: Review Article Source Type: research

Immunotherapy and Radiation Therapy for Non-Small Cell Lung Cancer —A Stimulating Partnership
Semin Respir Crit Care Med 2020; 41: 360-368 DOI: 10.1055/s-0039-3399578Non-small cell lung cancer (NSCLC) is the most common subtype of lung cancer and the leading cause of cancer-related death. Although durable local control rates are high after surgical resection or definitive radiotherapy for early-stage disease, a substantial proportion of these patients eventually experience regional and/or distant failure and succumb to their metastatic disease. The discovery of immunotherapeutics and targeted biologics has revolutionized the treatment of locally advanced and metastatic disease, improving progression-free and overal...
Source: Seminars in Respiratory and Critical Care Medicine - May 24, 2020 Category: Respiratory Medicine Authors: Dams, Ritchell van Yuan, Ye Robinson, Clifford G. Lee, Percy Tags: Review Article Source Type: research

Small Cell Lung Cancer: Advances in Diagnosis and Management
Semin Respir Crit Care Med 2020; 41: 435-446 DOI: 10.1055/s-0039-1700566Small cell lung cancer (SCLC) is an aggressive subtype of lung cancer characterized by rapid growth and early spread. It is a highly lethal disease that typically is diagnosed at a late stage. Surgery plays a very small role in this cancer, and management typically involves chemotherapy, delivered with thoracic radiation in early-stage disease. Platinum-based chemotherapy is initially very effective, inducing rapid and often deep responses. These responses, though, are transient, and upon relapse, SCLC is highly refractory to therapy. Immunotherapy has...
Source: Seminars in Respiratory and Critical Care Medicine - May 24, 2020 Category: Respiratory Medicine Authors: Chauhan, Ayushi F. Liu, Stephen V. Tags: Review Article Source Type: research

Imaging of Drug-Related Pneumonitis in Oncology
This article will describe the computed tomography (CT) pattern-based approach for drug-related pneumonitis that has been utilized to describe the imaging manifestations of pneumonitis from novel cancer therapies. Then, we will discuss pneumonitis from representative agents of precision cancer therapy, including mammalian target of rapamycin inhibitors, epidermal growth factor receptor inhibitors, and ICI, focusing on the incidence, risk factors, and the spectrum of CT patterns. Finally, the article will address emerging challenges in the diagnosis and monitoring of pneumonitis, including pneumonitis from combination ICI a...
Source: Seminars in Respiratory and Critical Care Medicine - October 28, 2022 Category: Respiratory Medicine Authors: Tseng, Shu-Chi Lee, Ho Yun Nishino, Mizuki Tags: Review Article Source Type: research

Content, quality, and readability of website information on dental care for patients with cancer
Conclusions: Websites addressing dental care for patients with cancer are broad in content yet are limited in quality and are written at difficult reading levels.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - April 10, 2014 Category: ENT & OMF Authors: Lauren L. Patton, Stephanie F. George, Robert P. Hollowell Tags: Oral Medicine Source Type: research

Cancer care spending and use by site of provider-administered chemotherapy in Medicare.
CONCLUSIONS: Differences in cancer care spending by site of chemotherapy (HOPDs vs POs) vary by service type. Those differences are partially driven by utilization differences. As the site of chemotherapy shifts from POs to HOPDs, spending and utilization patterns in both settings need to be monitored. PMID: 31211557 [PubMed - in process]
Source: The American Journal of Managed Care - May 31, 2019 Category: Health Management Authors: Shooshtari A, Kalidindi Y, Jung J Tags: Am J Manag Care Source Type: research

Manager, Nuclear Medicine
Conclusion: With each therapy, we have improved communication across our multi-disciplinary team. These improvements have been incorporated into a Sir-Sphere administration check list. Other improvements have been made to post treatment PET-CT image acquisition techniques.
Source: Journal of Nuclear Medicine - May 24, 2017 Category: Nuclear Medicine Authors: MacLean, J., Aguado, A., Gelfand, M. Tags: Technologist Posters Source Type: research

Durable Response to Nivolumab in a Pediatric Patient with Refractory Glioblastoma and Constitutional Biallelic Mismatch Repair Deficiency
In this report, we present the case of a 5‐year‐old female with GBM and CMMRD due to an MSH6 homozygous c.1883G>A mutation, who continues to experience an exceptional and durable response (9 months) to the immune checkpoint inhibitor (ICPI) nivolumab. Our patient presented with acute neurologic decline and increased intracranial pressure. Neuroimaging studies revealed a large left frontoparietal mass requiring neurosurgical decompression and resection. Histopathologic analyses resulted in a diagnosis of de novo GBM that was BRAF wild type and negative for programmed death‐ligand 1 protein expression. She received sta...
Source: The Oncologist - December 13, 2018 Category: Cancer & Oncology Authors: Musa AlHarbi, Nahla Ali Mobark, Latifa AlMubarak, Rasha Aljelaify, Mariam AlSaeed, Amal Almutairi, Fatmah Alqubaishi, M. Emarat Hussain, Ali Abdullah O. Balbaid, Amal Said Marie, Lamia AlSubaie, Saeed AlShieban, Nada alTassan, Shakti H. Ramkissoon, Malak Tags: Neuro-Oncology, Precision Medicine Precision Medicine Clinic: Molecular Tumor Board Source Type: research

Growth patterns during and after treatment in patients with pediatric ALL: A meta‐analysis
ConclusionsPatients with pediatric ALL experience unhealthy weight gain early in treatment, and increases in weight are maintained beyond treatment completion. Preventing early onset of obesity is a priority for improving the care and outcomes for patients with pediatric ALL. Pediatr Blood Cancer © 2015 Wiley Periodicals, Inc.
Source: Pediatric Blood and Cancer - March 24, 2015 Category: Cancer & Oncology Authors: Fang Fang Zhang, Shanshan Liu, Mei Chung, Michael J. Kelly Tags: Research Article Source Type: research

A pediatric brain tumor consortium phase II trial of capecitabine rapidly disintegrating tablets with concomitant radiation therapy in children with newly diagnosed diffuse intrinsic pontine gliomas
ConclusionCapecitabine did not improve the outcome for children with newly diagnosed DIPG.
Source: Pediatric Blood and Cancer - November 1, 2017 Category: Cancer & Oncology Authors: Lindsay B. Kilburn, Mehmet Kocak, Patricia Baxter, Tina Young Poussaint, Arnold C. Paulino, Christine McIntyre, Annabelle Lemenuel ‐Diot, Christine Lopez‐Diaz, Larry Kun, Murali Chintagumpala, Jack M. Su, Alberto Broniscer, Justin N. Baker, Eugene I. Tags: RESEARCH ARTICLE Source Type: research